Adaptyv Bio

Overview

Adaptyv Bio is a protein expression and characterization platform accessed via a REST API and Python SDK. Users submit protein sequences (antibodies, nanobodies, enzymes, binding proteins) and receive expressed protein along with binding affinity measurements (KD via biolayer interferometry) within days. The platform is designed for high-throughput directed evolution loops: generate candidate sequences (computationally or by library design) → order expression + assay via API → receive affinity data → retrain model or select top candidates → repeat. The SDK handles experiment submission, status polling, and result retrieval in Python.

When to Use

• Screening computationally designed protein variants for experimental binding affinity validation
• Running ML-guided directed evolution loops where in silico candidate generation alternates with wet-lab characterization
• Ordering cell-free expression of nanobodies, antibodies, or binding domains without maintaining wet-lab infrastructure
• Automating high-throughput protein characterization pipelines using the REST API
• Integrating experimental affinity data (KD values) with computational models for Bayesian optimization of protein sequences
• Validating ESM, AlphaFold, or docking predictions with experimental binding data
• Use benchling-integration for LIMS-style sequence and plasmid management; use Adaptyv Bio instead when you need automated cell-free expression and affinity characterization without wet-lab setup

Prerequisites