clinpgx-database
PharmGKB Clinical Pharmacogenomics Database
Overview
PharmGKB is the leading pharmacogenomics knowledge resource, curating how genetic variation affects drug response. It integrates CPIC (Clinical Pharmacogenomics Implementation Consortium) and DPWG (Dutch Pharmacogenomics Working Group) dosing guidelines, clinical annotations of variant-drug associations, gene-drug pathways, and literature evidence. The REST API provides free programmatic access without authentication to 24,000+ variant-drug annotations, 800+ clinical annotations, and 300+ CPIC guidelines.
When to Use
- Retrieving CPIC/DPWG clinical dosing guidelines for a specific gene-drug pair (e.g., CYP2C19-clopidogrel)
- Looking up all pharmacogenomic variants associated with a drug's response or toxicity
- Finding all drugs whose dosing is affected by variants in a pharmacogene (e.g., CYP2D6, DPYD)
- Retrieving PharmGKB clinical annotation levels (1A, 1B, 2A, 2B, 3, 4) for a variant-drug association
- Building precision medicine dosing workflows that incorporate genotype-guided prescribing
- Fetching pharmacogenomic pathways (e.g., warfarin pharmacokinetics/pharmacodynamics) with gene roles
- For cancer somatic pharmacogenomics use
cosmic-databaseoropentargets-database
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