DDInter Drug-Drug Interaction Database

Overview

DDInter is an open, curated database of drug-drug interactions (DDIs) covering 2,400+ drugs and 1.7M+ pairwise interactions with structured severity levels (major, moderate, minor), mechanistic annotations, and clinical management recommendations. Access is provided via a JSON REST API at https://ddinter.scbdd.com/api/ — no authentication or registration required.

When to Use

• Checking whether two co-administered drugs have a known interaction and its severity (major/moderate/minor)
• Retrieving all known interactions for a given drug to support polypharmacy risk assessment
• Identifying the mechanistic basis (pharmacokinetic vs. pharmacodynamic) of a drug-drug interaction
• Screening a drug combination list for potential major interactions before clinical decision support
• Building automated DDI checking pipelines for medication review or drug repurposing workflows
• Analyzing the DDI network for a drug class (e.g., all major interactions for CYP3A4 substrates)
• For FDA-approved drug labeling text (indications, dosage, contraindications) use dailymed-database
• For pharmacogenomics interactions (CYP genotype-drug associations) use clinpgx-database; DDInter covers drug-drug not gene-drug pairs
• For drug adverse event reports from FAERS use fda-database

Prerequisites