gtopdb-database
GtoPdb Database
Overview
The Guide to Pharmacology (GtoPdb), maintained by IUPHAR/BPS, is the curated reference database for pharmacological targets and their ligands. It covers 3,000+ targets (GPCRs, ion channels, nuclear receptors, catalytic receptors, transporters, and enzymes) with 12,000+ ligands and 90,000+ interaction records annotated with quantitative affinity values (Ki, IC50, EC50, Kd). Access is via a free REST API at https://www.guidetopharmacology.org/services/ — no authentication required.
When to Use
- Retrieving curated receptor-ligand interaction data with quantitative affinity (pKi, pIC50, pEC50) for GPCR, ion channel, or kinase targets
- Finding all approved drugs, clinical candidates, or research ligands that act on a specific receptor family
- Getting the pharmacological target classification for a receptor (family, type, HGNC symbol, UniProt ID)
- Building selectivity profiles for a ligand across all annotated targets in GtoPdb
- Identifying receptor families (GPCR subfamilies, ion channel families) and browsing their member targets
- Retrieving quantitative agonist/antagonist/allosteric modulator affinity data for lead optimization
- Comparing endogenous ligand potency with drug affinity at the same receptor
- For large-scale ADMET/bioactivity data use
chembl-database-bioactivity; GtoPdb is the authoritative source for receptor pharmacology annotation - For structural data (binding poses, crystal structures) use
pdb-database; GtoPdb provides affinity numbers, not 3D structures
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