Open Targets Platform Database

Overview

Open Targets Platform integrates evidence from genetics, genomics, literature, and drug databases to systematically score target-disease associations for 60,000+ targets and 20,000+ diseases/phenotypes. The public GraphQL API (no authentication required) provides access to association scores, evidence from 20+ data sources (GWAS, ClinVar, ChEMBL, drugs, pathways, mouse models, expression), and detailed drug-target-disease triangles.

When to Use

• Ranking therapeutic targets for a disease by overall association score and evidence breakdown
• Finding all diseases associated with a gene of interest and their confidence scores
• Retrieving approved and investigational drugs for a target, with mechanism of action and clinical phase
• Assessing target druggability and tractability (small molecule, antibody, PROTAC likelihood)
• Pulling genetic association evidence (GWAS hits, variant-to-gene mappings) for a target-disease pair
• Exploring safety/adverse event data for a drug target from FAERS and literature
• For bioactivity IC50/Ki data use chembl-database-bioactivity; for clinical trial details use clinicaltrials-database-search

Prerequisites