Develop a GC Method

Systematic development of a gas chromatography method covering column selection, temperature program optimization, carrier gas and detector choice, and initial performance verification for volatile and semi-volatile analytes.

When to Use

• Starting a new GC analysis for volatile or semi-volatile compounds
• Adapting a published method to a different instrument or matrix
• Replacing an existing method that no longer meets performance requirements
• Developing a method for compounds with known boiling points and polarities
• Transitioning from a packed-column method to a capillary method

Inputs

Required

• Target analytes: List of compounds with CAS numbers, molecular weights, and boiling points
• Sample matrix: Description of the sample type (e.g., air, water extract, solvent solution, biological fluid)
• Detection limits: Required LOD/LOQ for each analyte