binder-design
Installation
SKILL.md
Binder Design Tool Selection
Which tool wins
No single tool is best for every target. Hit-rate is strongly target-dependent, so choose by target type, what you want to control, and available compute.
The clearest signal comes from head-to-head competitions where many methods design against the same target. On the Adaptyv Nipah de novo target, the public results show:
| Method | Tested | Binders | Hit-rate |
|---|---|---|---|
| Mosaic (gradient, multi-model) | 9 | 8 | 89% |
| ProteinMPNN hybrid | 28 | 7 | 25% |
| RFdiffusion | 60 | 13 | 22% |
| BindCraft | 98 | 7 | 7% |
| BoltzGen | 182 | 6 | 3% |