Mosaic Multi-Objective Design

Mosaic (Escalante Bio) is a JAX framework for "functional, multi-objective protein design using continuous relaxation." It optimizes a soft sequence by gradient descent over a continuous relaxation of sequence space, in the lineage of ColabDesign, RSO, and BindCraft, with one key difference: it composes multiple learned objectives from different models in a single differentiable loss.

When Mosaic fits

Mosaic is a framework for custom objectives, not a one-click method. The README is explicit: it "may require substantial hand-holding (tuning learning rates, etc), often produces proteins that fail simple in-silico tests, [and] should be combined with standard filtering methods." Reach for it when a fixed pipeline cannot express the objective you need. For a turnkey binder run, use bindcraft instead.

Prerequisites