Protein Design Quality Control

Critical Limitation

Individual metrics have weak predictive power for binding. Research shows:

• Individual metric ROC AUC: 0.64-0.66 (slightly better than random)
• Metrics are pre-screening filters, not affinity predictors
• Composite scoring is essential for meaningful ranking

These thresholds filter out poor designs but do NOT predict binding affinity.

QC Organization

QC is organized by purpose and level: