Source: https://github.com/aipoch/medical-research-skills

Clinical Study Bias Assessment (QUADAS-2)

This skill evaluates clinical diagnostic accuracy studies for bias and applicability concerns using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool.

Workflow

To assess a study, follow these steps:

1. Analyze Patient Selection:

   • Assess if the sample was consecutive or random.
   • Check for case-control design (should be avoided).
   • Check for inappropriate exclusions.
   • See references/quadas_2_criteria.md for detailed signaling questions.

2. Analyze Index Test:

   • Assess if the index test results were interpreted without knowledge of the reference standard.
   • Check if the threshold was pre-specified.