open-targets-db
Installation
SKILL.md
When to Use
- You have a disease (e.g., an EFO ID) and want to discover and prioritize candidate therapeutic targets.
- You have a target (e.g., an Ensembl gene ID) and need to review associated diseases and supporting evidence.
- You need evidence-level details (e.g., GWAS, ClinVar, ChEMBL) to justify or audit a target-disease association.
- You want to compare association strength across targets/diseases using Open Targets evidence scoring.
- You are building a pipeline that programmatically fetches curated target-disease associations from Open Targets.
Key Features
- Entity querying by type:
target,disease, orevidence. - Target discovery for diseases using Open Targets associations.
- Association scoring based on Open Targets evidence aggregation (harmonic-sum style aggregation across evidence sources).
- Evidence retrieval from integrated sources such as GWAS, ClinVar, ChEMBL, pathways, and other curated datasets.
- Field selection to request only specific fields (optional) for smaller payloads.