Transcription Factor (TF) Regulatory Network Analysis

When to Use

• Use this skill when you have a human or mouse gene list and want to identify upstream TFs from the Dorothea database.
• Use it when you need a ready-to-export TF-target network table plus a publication-ready PDF network plot.
• Use it for reproducible CLI execution with saved session information and optional local Dorothea .rds databases.

When Not to Use

• Do not use this skill for differential expression, pathway enrichment, cell type annotation, or survival analysis.
• Do not use it to infer causal direction beyond curated Dorothea TF-target relationships.
• Do not use it when your input genes are aliases or mixed-species symbols that have not been normalized first.

Input Validation

This skill accepts: a human or mouse gene list (HGNC symbols for human, first-letter-uppercase for mouse) for TF regulatory network analysis using Dorothea.