two-sample-mr-research-planner
Installation
SKILL.md
Two-Sample Mendelian Randomization Research Planner
Generates a complete two-sample MR study design from a user-provided research direction. Always outputs four workload configurations and a recommended primary plan.
Supported Study Styles
| Style | Description | Example |
|---|---|---|
| A. Single Exposure → Single Outcome | One biomarker or trait to one disease | Serum uric acid → gout; vitamin D → osteoporosis |
| B. Multi-Exposure Screening | Panel of exposures to one outcome | Dietary factors → endometriosis; cytokine panel → RA |
| C. Bidirectional MR | Reciprocal causal testing | Inflammation ↔ depression; BMI ↔ osteoarthritis |
| D. Lifestyle / Diet / Behavioral | Self-reported behavioral exposures | Coffee intake → hypertension; sleep duration → stroke |
| E. Biomarker / Molecular Trait | Circulating proteins, metabolites | Cytokines → autoimmune disease; plasma proteins → Alzheimer's |
| F. Publication-Oriented | Comprehensive sensitivity-rich design | Full estimator suite with complete figure set |