AlphaFold (via ColabFold)

Overview

Predict a protein's 3D structure from its amino-acid sequence with AlphaFold2, run through ColabFold (Mirdita et al., Nature Methods 2022) — which replaces AlphaFold's slow genetic-database MSA search with the fast MMseqs2 API, making folding practical on a single GPU. Handles single chains (monomer) and complexes via AlphaFold2-Multimer (Evans et al. 2021), and reports per-residue and per-interface confidence metrics so you know which parts of a prediction to trust.

This skill runs folding and returns structures + confidence. To retrieve an already-computed AlphaFold prediction for a known UniProt entry without running anything, use alterlab-alphafold-db instead.

When to Use This Skill