GTEx Database

Overview

The Genotype-Tissue Expression (GTEx) project provides a comprehensive resource for studying tissue-specific gene expression and genetic regulation across 54 non-diseased human tissues from nearly 1,000 individuals. GTEx v10 (the latest release) enables researchers to understand how genetic variants regulate gene expression (eQTLs) and splicing (sQTLs) in a tissue-specific manner, which is critical for interpreting GWAS loci and identifying regulatory mechanisms.

Key resources:

• GTEx Portal: https://gtexportal.org/
• GTEx API v2: https://gtexportal.org/api/v2/
• Data downloads: https://gtexportal.org/home/downloads/adult-gtex/
• Documentation: https://gtexportal.org/home/documentationPage

When to Use This Skill

Use GTEx when: