InterPro Database

Overview

InterPro (https://www.ebi.ac.uk/interpro/) is a comprehensive resource for protein family and domain classification maintained by EMBL-EBI. It integrates predictive signatures from its member databases — including Pfam, PANTHER, PRINTS, ProSite, SMART, NCBIfam, SUPERFAMILY, CDD, Gene3D, and others (see the member-database table below) — into a unified set of entries, providing a single view of functional annotation across UniProtKB. (The legacy TIGRFAMs were absorbed into NCBIfam.)

InterPro classifies proteins into:

• Families: Groups of proteins sharing common ancestry and function
• Domains: Independently folding structural/functional units
• Homologous superfamilies: Structurally similar protein regions
• Repeats: Short tandem sequences
• Sites: Functional sites (active, binding, PTM)

Key resources:

• InterPro website: https://www.ebi.ac.uk/interpro/
• REST API: https://www.ebi.ac.uk/interpro/api/
• API documentation: https://github.com/ProteinsWebTeam/interpro7-api/blob/master/docs/
• Python client: via requests