Drug Repurposing

Overview

This skill teaches the agent how to reason about drug repurposing — identifying approved or clinical-stage compounds that may treat a new indication. Repurposing succeeds when three conditions align: (1) a credible mechanistic link between the drug and the new disease, (2) sufficient evidence strength from orthogonal sources, and (3) a realistic translatability path given existing safety, PK, formulation, and IP data.

Use this skill to evaluate proposals, rank candidates, spot weak evidence, and guide the user toward a defensible repurposing strategy before committing to wet-lab or clinical work.

Usage

Invoke this skill when the user:

• Has a disease target and wants to find approved drugs that modulate it.
• Has a disease transcriptomic signature and wants to find drugs with opposing profiles.
• Asks how to query DGIdb, OpenTargets, ChEMBL, or DrugBank for repurposing candidates.
• Claims a drug "should work" for a new indication based on a single data source.
• Wants to rank multiple repurposing candidates by evidence strength.
• Asks whether a repurposing candidate is translatable to clinical trials.
• Needs to design a repurposing study or write a repurposing rationale.