Drug Discovery Pipeline (Meta Skill)

This meta-skill orchestrates a multi-stage drug discovery workflow by combining target validation, compound searching, property filtering, and lead optimization into a single coherent pipeline. It coordinates four specialized skills to move from a biological target to a ranked list of drug candidates.

Workflow

Step 1: Target Validation

Query UniProt for the target protein to gather functional annotations, known domains, post-translational modifications, and disease associations. Assess druggability by checking for known binding pockets, ligand-binding domains, and membership in established druggable protein families (kinases, GPCRs, ion channels, nuclear receptors).

Step 2: Known Drug and Compound Survey