hic-normalization

Overview

This skill performs Hi-C data normalization on .mcool files.
Main steps include:

• Refer to the Inputs & Outputs section to verify required files and output structure.
• Check normalization status per resolution (supports bins/weight columns only).
• If a resolution is not normalized, perform normalization with cooler balance (ICE) to create bins/weight.
• Verify normalization and emit a concise report on the file, resolution, and normalization status.

When to use this skill

Use the hic-normalization pipeline when:

• You need to ensure that Hi-C data is normalized for downstream analysis.
• Your data comes in .cool or .mcool formats, and you want to check or refresh normalization status (ICE normalization).