HOMER Known Motif Enrichment

Overview

This skill enables comprehensive known motif enrichment analysis using HOMER tools for genomic peak files. It identifies enrichment of known transcription factor binding motifs from established databases in genomic regions.

When to use this skill

Use this skill when you need to uncover the enrichment of a certain motif in the promoter regions of a set of genes, or directly from a set of genomic regions, such as peaks from ChIP-seq or ATAC-seq, with prior assumptions about which transcription factors are involved. Typical use cases include:

• Calculate the enrichment of a certain motif in the whole genome or in specific genomic regions, like promoters of a gene list or peaks from ChIP-seq or ATAC-seq.

Inputs & Outputs

Inputs