Conducting Meta-Analyses

Why This Skill Exists

Meta-analysis quantitatively synthesizes results across multiple studies to produce pooled effect estimates with greater precision than any individual trial. It is the statistical engine behind systematic reviews, health technology assessments, and regulatory benefit-risk evaluations. Poorly conducted meta-analyses — using inappropriate pooling models, ignoring heterogeneity, or failing to assess publication bias — produce misleading conclusions that can harm patients and distort policy. This skill implements Cochrane Handbook methodology, PRISMA reporting standards, and GRADE evidence assessment for defensible quantitative synthesis.

Checkpoint A — Intake and Scoping