DepMap — Cancer Dependency Map

Overview

The Cancer Dependency Map (DepMap) project, run by the Broad Institute, systematically characterizes genetic dependencies across hundreds of cancer cell lines using genome-wide CRISPR knockout screens (DepMap CRISPR), RNA interference (RNAi), and compound sensitivity assays (PRISM). DepMap data is essential for:

• Identifying which genes are essential for specific cancer types
• Finding cancer-selective dependencies (therapeutic targets)
• Validating oncology drug targets
• Discovering synthetic lethal interactions

Key resources:

• DepMap Portal: https://depmap.org/portal/
• DepMap data downloads: https://depmap.org/portal/download/all/
• Python package: depmap (or access via API/downloads)
• API: https://depmap.org/portal/api/

When to Use This Skill

Use DepMap when: