Bio Database Evidence

Use This Skill For

Use this skill when the main task is biological database lookup, annotation, or evidence gathering across one or more biological sources:

Gene annotation, identifiers, RefSeq, Ensembl IDs, orthologs, VEP, GO, and genomic coordinates.
Variant clinical significance, VUS interpretation support, ClinVar review status, cancer mutations, and COSMIC evidence.
GWAS Catalog trait associations, rs IDs, p-values, summary statistics, and genetic epidemiology evidence.
Pathway mapping, ID conversion, KEGG pathways, Reactome enrichment, disease pathways, and pathway evidence.
Target-disease association evidence, tractability, safety, known drugs, and Open Targets evidence.
Protein structure evidence from AlphaFold DB or RCSB PDB, including UniProt IDs, mmCIF/PDB downloads, pLDDT, PAE, and structure metadata.
Protein-protein interaction evidence, STRING networks, hub proteins, and enrichment evidence.
Reference single-cell data lookup from CELLxGENE Census when the user asks for census metadata or expression data, not full downstream analysis.
Cross-database biological ID mapping and evidence tables across multiple resources.