Spatial Cell-Cell Communication

Overview

Expression-based ligand-receptor (LR) inference ranks pairs that could signal; spatial data adds whether sender and receiver actually sit next to each other. This skill runs one inference (LIANA consensus by default, or CellPhoneDB statistics), puts the result into one table, keeps interactions whose cell types are spatial neighbours, scores LR co-expression at each location, and narrows the table to the user's question with an evidence class per candidate. Expression of both partners never proves signalling: every result is a candidate.