STRING Database — Protein-Protein Interactions

Overview

Query the STRING protein-protein interaction database (59M proteins, 20B+ interactions, 5000+ species) via REST API. Covers network retrieval, functional enrichment (GO, KEGG, Pfam), interaction partner discovery, PPI enrichment testing, network visualization, and homology analysis.

When to Use

• Retrieving protein-protein interaction networks for one or multiple proteins
• Performing functional enrichment analysis (GO, KEGG, Pfam, InterPro) on protein lists
• Discovering interaction partners and expanding protein networks from seed proteins
• Testing whether a set of proteins forms a significantly enriched functional module
• Generating network visualizations with evidence-based coloring
• Analyzing homology and protein family relationships across species
• Identifying hub proteins and network connectivity patterns
• For chemical compound interactions use chembl-database-bioactivity instead; for pathway-centric queries use kegg-database

Prerequisites