Boltz-2

Boltz-2 is the open-weights diffusion co-folder closest in surface to AlphaFold3: a YAML describing protein, DNA, RNA, and ligand chains in, mmCIF plus pTM/ipTM/pLDDT confidences out, with an optional small-molecule affinity head. Among our four co-fold skills it is the default for binder-validation campaigns — fully open MIT weights and the fastest sampler; pick chai1 when you want a second independent model for consensus, openfold3 when AF3-faithful settings matter, and esmfold2 when you can live without an MSA. Code and weights are MIT (PyPI boltz, github.com/jwohlwend/boltz).

Running it