ESMFold2 (Biohub)

All-atom diffusion co-folding from the Biohub ESM release (2026). ESMFold2 = 48 pair layers with MSA support; ESMFold2-Fast = 24 layers, single-sequence only, ~1.7x faster.

License: MIT (code github.com/Biohub/esm + weights HF biohub/*). Paper: "Language Modeling Materializes a World Model of Protein Biology" (2026).

Install

CUDA 12.x GPU (H100/A100-class); Python 3.12 only. Fresh venv; needs egress to HF Hub, GitHub, PyPI: