bindingdb-database
BindingDB Database
Overview
BindingDB (https://www.bindingdb.org/) is the primary public database of measured drug-protein binding affinities. It contains over 3 million binding data records for ~1.4 million compounds tested against ~9,200 protein targets, curated from scientific literature and patent literature. BindingDB stores quantitative binding measurements (Ki, Kd, IC50, EC50) essential for drug discovery, pharmacology, and computational chemistry research.
Key resources:
- BindingDB website: https://www.bindingdb.org/
- REST API: https://www.bindingdb.org/axis2/services/BDBService
- Downloads: https://www.bindingdb.org/bind/chemsearch/marvin/Download.jsp
- GitHub: https://github.com/drugilsberg/bindingdb
When to Use This Skill
Use BindingDB when:
- Target-based drug discovery: What known compounds bind to a target protein? What are their affinities?
- SAR analysis: How do structural modifications affect binding affinity for a series of analogs?
- Lead compound profiling: What targets does a compound bind (selectivity/polypharmacology)?
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