depmap
DepMap — Cancer Dependency Map
Overview
The Cancer Dependency Map (DepMap) project, run by the Broad Institute, systematically characterizes genetic dependencies across hundreds of cancer cell lines using genome-wide CRISPR knockout screens (DepMap CRISPR), RNA interference (RNAi), and compound sensitivity assays (PRISM). DepMap data is essential for:
- Identifying which genes are essential for specific cancer types
- Finding cancer-selective dependencies (therapeutic targets)
- Validating oncology drug targets
- Discovering synthetic lethal interactions
Key resources:
- DepMap Portal: https://depmap.org/portal/
- DepMap data downloads: https://depmap.org/portal/download/all/
- Python package:
depmap(or access via API/downloads) - API: https://depmap.org/portal/api/
When to Use This Skill
Use DepMap when:
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