gtex-database
GTEx Database
Overview
The Genotype-Tissue Expression (GTEx) project provides a comprehensive resource for studying tissue-specific gene expression and genetic regulation across 54 non-diseased human tissues from nearly 1,000 individuals. GTEx v10 (the latest release) enables researchers to understand how genetic variants regulate gene expression (eQTLs) and splicing (sQTLs) in a tissue-specific manner, which is critical for interpreting GWAS loci and identifying regulatory mechanisms.
Key resources:
- GTEx Portal: https://gtexportal.org/
- GTEx API v2: https://gtexportal.org/api/v2/
- Data downloads: https://gtexportal.org/home/downloads/adult-gtex/
- Documentation: https://gtexportal.org/home/documentationPage
When to Use This Skill
Use GTEx when:
- GWAS locus interpretation: Identifying which gene a non-coding GWAS variant regulates via eQTLs
- Tissue-specific expression: Comparing gene expression levels across 54 human tissues
- eQTL colocalization: Testing if a GWAS signal and an eQTL signal share the same causal variant
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