interpro-database
InterPro Database
Overview
InterPro (https://www.ebi.ac.uk/interpro/) is a comprehensive resource for protein family and domain classification maintained by EMBL-EBI. It integrates signatures from 13 member databases including Pfam, PANTHER, PRINTS, ProSite, SMART, TIGRFAM, SUPERFAMILY, CDD, and others, providing a unified view of protein functional annotations for over 100 million protein sequences.
InterPro classifies proteins into:
- Families: Groups of proteins sharing common ancestry and function
- Domains: Independently folding structural/functional units
- Homologous superfamilies: Structurally similar protein regions
- Repeats: Short tandem sequences
- Sites: Functional sites (active, binding, PTM)
Key resources:
- InterPro website: https://www.ebi.ac.uk/interpro/
- REST API: https://www.ebi.ac.uk/interpro/api/
- API documentation: https://github.com/ProteinsWebTeam/interpro7-api/blob/master/docs/
- Python client: via
requests
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