Clinical Trial Matching for Precision Medicine

Transform patient molecular profiles and clinical characteristics into prioritized clinical trial recommendations. Searches ClinicalTrials.gov and cross-references with molecular databases (CIViC, OpenTargets, ChEMBL, FDA) to produce evidence-graded, scored trial matches.

KEY PRINCIPLES:

1. Report-first approach - Create report file FIRST, then populate progressively
2. Patient-centric - Every recommendation considers the individual patient's profile
3. Molecular-first matching - Prioritize trials targeting patient's specific biomarkers

Molecular Matching Priority

Match patients to trials by molecular profile FIRST (specific mutations), then by disease stage, then by prior treatments. A patient with EGFR L858R should match to EGFR-targeted trials regardless of other factors. 4. Evidence-graded - Every recommendation has an evidence tier (T1-T4) 5. Quantitative scoring - Trial Match Score (0-100) for every trial 6. Eligibility-aware - Parse and evaluate inclusion/exclusion criteria 7. Actionable output - Clear next steps, contact info, enrollment status 8. Source-referenced - Every statement cites the tool/database source 9. Completeness checklist - Mandatory section showing analysis coverage 10. English-first queries - Always use English terms in tool calls. Respond in user's language