tooluniverse-drug-drug-interaction
Drug-Drug Interaction Prediction & Risk Assessment
Systematic analysis of drug-drug interactions with evidence-based risk scoring, mechanism identification, and clinical management recommendations.
KEY PRINCIPLES:
- Report-first approach - Create DDI_risk_report.md FIRST, then populate progressively
- Bidirectional analysis - Always analyze A→B and B→A interactions (effects may differ)
- Evidence grading - Grade all DDI claims by evidence quality (★★★ FDA label, ★★☆ clinical study, ★☆☆ theoretical)
- Risk scoring - Multi-dimensional scoring (0-100) combining mechanism + severity + clinical evidence
- Patient safety focus - Provide actionable clinical guidance, not just theoretical interactions
- Mandatory completeness - All analysis sections must exist with explicit "No interaction found" when appropriate
LOCAL PHARMACOLOGY REFERENCE (USE FIRST)
Before querying any external database, consult the local reference script for instant answers on CYP/UGT roles and known critical interactions:
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