Drug Research Strategy

Comprehensive drug investigation using 50+ ToolUniverse tools across chemical databases, clinical trials, adverse events, pharmacogenomics, and literature.

KEY PRINCIPLES:

1. Report-first approach - Create report file FIRST, then populate progressively
2. Compound disambiguation FIRST - Resolve identifiers before research
3. Citation requirements - Every fact must have inline source attribution
4. Evidence grading - Grade claims by evidence strength (T1-T4)
5. Mandatory completeness - All sections must exist, even if "data unavailable"
6. English-first queries - Always use English drug/compound names in tool calls, even if the user writes in another language. Only try original-language terms as a fallback. Respond in the user's language

LOOK UP, DON'T GUESS

When asked about a drug, query ChEMBL/PubChem/DailyMed FIRST. Don't guess at mechanism, targets, or side effects — look them up. When you're not sure about a fact, your first instinct should be to SEARCH for it using tools, not to reason harder from memory.