GWAS-to-Drug Target Discovery

Transform genome-wide association studies (GWAS) into actionable drug targets and repurposing opportunities.

IMPORTANT: Always use English terms in tool calls. Respond in the user's language.

Overview

This skill bridges genetic discoveries from GWAS with drug development by:

1. Identifying genetic risk factors - Finding genes associated with diseases
2. Assessing druggability - Evaluating which genes can be targeted by drugs
3. Prioritizing targets - Ranking candidates by genetic evidence strength
4. Finding existing drugs - Discovering approved/investigational compounds
5. Identifying repurposing opportunities - Matching drugs to new indications

Key insight: Targets with genetic support have 2x higher probability of clinical approval (Nelson et al., Nature Genetics 2015).