tooluniverse-gwas-study-explorer
GWAS Study Deep Dive & Meta-Analysis
Compare GWAS studies, perform meta-analyses, and assess replication across cohorts
Overview
The GWAS Study Deep Dive & Meta-Analysis skill enables comprehensive comparison of genome-wide association studies (GWAS) for the same trait, meta-analysis of genetic loci across studies, and systematic assessment of replication and study quality. It integrates data from the NHGRI-EBI GWAS Catalog and Open Targets Genetics to provide a complete picture of the genetic architecture of complex traits.
Key Capabilities
- Study Comparison: Compare all GWAS studies for a trait, assessing sample sizes, ancestries, and platforms
- Meta-Analysis: Aggregate effect sizes across studies and calculate heterogeneity statistics
- Replication Assessment: Identify replicated vs novel findings across discovery and replication cohorts
- Quality Evaluation: Assess statistical power, ancestry diversity, and data availability
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