Pharmacokinetic (PK) Analysis — Non-Compartmental Analysis

Turn a concentration-vs-time profile after a dose into the standard PK parameters, and compute bioavailability from IV + oral data. Non-compartmental analysis (NCA) is the model-independent workhorse used for most PK reporting.

When to use this

• You have measured plasma/serum (or other matrix) drug concentrations at known times after a dose.
• You need Cmax/Tmax/AUC/half-life/clearance/Vd, or absolute bioavailability F.
• Comparing exposure (AUC, Cmax) between formulations, doses, or routes.

This is measured-data PK. For predicting ADMET properties from a chemical structure, use tooluniverse-admet-prediction.

Step 1 — Prepare the concentration-time data