Residue functional mechanism interpretation

The core user question: "Why are these residues functionally critical?"

Answering needs more than one source: a residue in the ligand pocket means something different from one in a catalytic triad, an interface, the hydrophobic core, or a PTM sequon. This skill synthesizes evidence from multiple TU tools to call a mechanism for each residue (or cluster of adjacent residues).

The residues can come from any source — this skill is agnostic to where they came from: