tooluniverse-variant-functional-annotation
Pass
Audited by Gen Agent Trust Hub on Oct 7, 2026
Risk Level: SAFE
Full Analysis
- [COMMAND_EXECUTION]: The skill encourages writing and running Python code via Bash for data processing and statistical analysis. It explicitly names common analytical libraries (pandas, scipy, statsmodels, matplotlib) to be used for these tasks.
- [DYNAMIC_EXECUTION]: The workflow involves generating Python scripts to synthesize data retrieved from various annotation tools. This is the primary functional purpose of the skill and is constrained to the context of variant interpretation.
- [INDIRECT_PROMPT_INJECTION]: The skill accepts external input in the form of genomic coordinates, rsIDs, and protein variant notations. These inputs are passed to specific tool parameters (e.g., ProtVar, ClinVar, gnomAD) for scientific lookup, which significantly reduces the risk of malicious instruction injection via data.
- [EXTERNAL_DOWNLOADS]: The skill references several external scientific services including ProtVar, ClinVar, gnomAD, CADD, ClinGen, and FAVOR. These are widely recognized and trusted public databases within the bioinformatics and clinical genetics community.
Audit Metadata