Complexa Binder Design (workflow)

From one request — "design binders for <target>" — to ranked, independently validated binders. Each returned binder is a co-designed sequence + predicted binder–target complex, gated by interface confidence, by whether the binder actually contacts the target hotspots, and by apo/holo stability.

Generation uses Proteina-Complexa (co-designs binder sequence + full-atom structure together — no inverse-folding step — with reward-guided test-time search). Validation uses a different model family (Boltz2 / OpenFold3), so the headline confidence is an independent check, not the generator grading its own homework.

Upstream model + code (you provide these):

• Project page: https://research.nvidia.com/labs/genair/proteina-complexa/
• Code: https://github.com/NVIDIA-Digital-Bio/Proteina-Complexa (the complexa CLI)
• Weights (NGC): nvidia/clara/proteina_complexa
• Paper: Didi et al., Scaling Atomistic Protein Binder Design…, ICLR 2026.