ProteinMPNN NIM

Design protein sequences for a supplied backbone PDB. Use this SKILL.md for first-pass hosted/local usage; load supplemental files only when needed:

• references/api.md: exact endpoints, schemas, Docker flags, response fields.
• references/science.md: inverse-folding uses, limits, and validation.
• references/parameters.md: design controls, fixed positions, sampling.
• references/validation.md: FASTA, score, and structure checks.
• references/examples.md: compact hosted/local request patterns.

Choose Mode

Honor an explicitly configured runtime before asking. NIM_API_MODE=local selects the local service at PROTEINMPNN_NIM_URL; the URL defaults to http://localhost:8000 for a NIM running in the same host or container. Ask only when neither the environment nor the user's request makes the mode clear:

Hosted NVIDIA API or local Docker NIM?