RFD4-Proteína Reward-Guided Search

Purpose

Reward requirements

Complete rfd4-proteina-setup first. Generation requires a CUDA GPU. Rewards listing refolding oracles also require a configured refolding backend; RFD4-Proteína supports AF2, AF3, and OpenFold3 through metrics/refolding_oracles. Rewards such as interchain_interactions do not require a refolding oracle.

Search explores multiple generation trajectories and keeps the candidates a reward scores highest. Beam search ships ready to run: it branches and prunes partial trajectories at step checkpoints, scoring survivors with a reward model. The shipped inference_beam_example uses the default AF3 oracle for refolding confidence; other search configs may select another backend or avoid refolding entirely.