Adaptive Trial Simulator

Statistical simulation platform for designing and validating adaptive clinical trial designs in silico. Enables optimization of interim analysis strategies, sample size adaptation, and early stopping rules while maintaining Type I error control.

Features

• Design Simulation: Monte Carlo validation of adaptive designs
• Sample Size Re-estimation: Adapt sample size based on interim data
• Early Stopping Rules: Futility and efficacy boundary optimization
• Type I Error Control: Validate alpha spending strategies
• Multi-Arm Designs: Drop-the-loser and seamless Phase II/III
• Power Optimization: Identify designs with maximum power efficiency

Usage

Basic Usage