bio-atac-seq-differential-accessibility
Installation
SKILL.md
Version Compatibility
Reference examples tested with: DESeq2 1.42+, GenomicRanges 1.54+, Subread 2.0+, numpy 1.26+, pandas 2.2+, scanpy 1.10+, scipy 1.12+
Before using code patterns, verify installed versions match. If versions differ:
- Python:
pip show <package>thenhelp(module.function)to check signatures - R:
packageVersion('<pkg>')then?function_nameto verify parameters - CLI:
<tool> --versionthen<tool> --helpto confirm flags
If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying.
Differential Accessibility
"Find differentially accessible regions between my conditions" → Identify chromatin regions with statistically significant changes in accessibility between treatment groups, cell types, or timepoints.
- R:
DiffBindorDESeq2on a peak-by-sample count matrix