Version Compatibility

Reference examples tested with: MutationalPatterns 3.12+, SigProfilerExtractor 1.1+, numpy 1.26+

Before using code patterns, verify installed versions match. If versions differ:

• Python: pip show <package> then help(module.function) to check signatures
• R: packageVersion('<pkg>') then ?function_name to verify parameters

If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying.

Somatic Mutational Signatures

"Extract mutational signatures from my tumor samples" → Decompose somatic mutation catalogs into mutational signatures (SBS, DBS, ID) to identify DNA damage mechanisms and mutagenic processes in cancer genomes.

• Python: SigProfilerExtractor.sigpro() for de novo signature extraction
• R: MutationalPatterns::fit_to_signatures() for fitting to COSMIC signatures

SigProfiler Workflow