Version Compatibility

Reference examples tested with: cooler 0.9+, cooltools 0.6+, matplotlib 3.8+, numpy 1.26+, pandas 2.2+, scipy 1.12+, statsmodels 0.14+

Before using code patterns, verify installed versions match. If versions differ:

• Python: pip show <package> then help(module.function) to check signatures

If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying.

Hi-C Differential Analysis

"Compare Hi-C contacts between my conditions" → Compute log2 fold-change contact maps, identify statistically significant differential interactions, and visualize changes in 3D genome organization.

• Python: cooltools for expected values, custom differential analysis with scipy.stats

Compare Hi-C contact matrices between conditions.

Required Imports