bio-tcr-bcr-analysis-immcantation-analysis
Installation
SKILL.md
Version Compatibility
Reference examples tested with: MiXCR 4.6+, ggplot2 3.5+
Before using code patterns, verify installed versions match. If versions differ:
- R:
packageVersion('<pkg>')then?function_nameto verify parameters
If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying.
Immcantation Analysis
"Analyze B cell repertoire evolution and clonal lineages" → Study somatic hypermutation, build B cell phylogenies, and track affinity maturation using the Immcantation framework for BCR repertoire analysis.
- R:
alakazam::plotMutability(),dowser::buildPhylipLineage(),scoper::spectralClones()
Requires Immcantation suite: alakazam 1.3+, shazam 1.2+, scoper 1.3+, dowser 2.0+, tigger 1.1+.