Individual Patient Data (IPD) Meta-Analysis

This skill teaches IPD meta-analysis, the "gold standard" of evidence synthesis that uses raw participant-level data from multiple studies.

Overview

IPD meta-analysis analyzes the original individual-level data from each study rather than summary statistics. This enables more powerful analyses, proper handling of time-to-event data, and exploration of patient-level effect modifiers.

When to Use This Skill

Activate this skill when users:

• Have access to individual patient data from multiple trials
• Want to explore subgroup effects or treatment-effect modifiers
• Need to analyze time-to-event (survival) outcomes
• Ask about one-stage vs two-stage approaches
• Want to standardize outcomes across studies
• Need to handle missing data properly

Core Concepts to Teach