ipsae
Installation
SKILL.md
ipSAE Binder Ranking
Prerequisites
| Requirement | Minimum | Recommended |
|---|---|---|
| Python | 3.8+ | 3.10 |
| NumPy | 1.20+ | Latest |
| RAM | 8GB | 16GB |
Overview
ipSAE (interprotein Score from Aligned Errors) is a scoring function for ranking protein-protein interactions predicted by AlphaFold2, AlphaFold3, and Boltz1. It outperforms ipTM and iPAE for binder design ranking with 1.4x higher precision in identifying true binders.
Paper: What's wrong with AlphaFold's ipTM score