MetabolicFeatures Process Configuration

Purpose

Performs enrichment analysis (GSEA-based) for metabolic pathways across different cell groups to identify significantly enriched pathways. Uses fast gene set enrichment analysis (fgsea package) to rank pathways by their association with specific clusters, conditions, or cell states. Generates summary plots and enrichment visualizations for biological interpretation.

When to Use

• Identify differentially active pathways: When you need to find which metabolic pathways are enriched in specific cell groups
• Compare pathway enrichment: To identify metabolic differences between clusters, treatments, or conditions
• After pathway activity scoring: Complements MetabolicPathwayActivity by providing statistical enrichment (p-values, FDR)
• Part of ScrnaMetabolicLandscape: Runs in parallel with MetabolicPathwayActivity and MetabolicPathwayHeterogeneity
• GSEA-based analysis: When you want enrichment scores based on ranked gene lists (signal-to-noise, t-test, fold change)

Configuration Structure